GHK-Cu

Overview

GHK-Cu (copper tripeptide-1) is a naturally occurring copper-binding tripeptide found in human blood plasma, saliva, and urine. Unusually for a research peptide, it wasn't synthesized to mimic a biological signal — it was discovered as a substance the body already produces, in higher concentrations in younger people.

Proposed Mechanism

Occurs naturally in human plasma and declines with age. Laboratory studies show it can activate genes governing collagen and connective-tissue synthesis, and support copper-dependent antioxidant enzyme activity.

Research Context

The observation that GHK-Cu levels decline measurably with age is what originally drove research interest. Since then, research has expanded into its effects on collagen and connective-tissue gene expression, wound healing, and antioxidant enzyme activity that depends on its copper-binding property.

Evidence Status — Well-documented

Well-documented for topical and dermal research; injectable systemic research is a comparatively newer body of literature.

Topical and dermal research on GHK-Cu is comparatively mature, including cell-culture studies showing it activates genes involved in collagen and glycosaminoglycan production. Injectable, systemic research is a newer and smaller body of literature by comparison — most of the well-established evidence relates to topical/local application rather than systemic administration.

Research Use Only

This page is a scientific reference summarizing publicly available research literature. It contains no dosing, administration, or protocol guidance, and nothing here constitutes medical advice. BactoCore does not sell this or any peptide referenced in this index — the only product sold directly is bacteriostatic water. See the Safety section for who should not handle research compounds, and the Research Use Disclaimer for full terms.