PE-22-28

Overview

PE-22-28 is a synthetic analog of spadin, a peptide that blocks TREK-1 potassium channels — ion channels found in the brain that play a role in mood regulation through a mechanism distinct from the monoamine-reuptake systems that most conventional antidepressant medications target.

Proposed Mechanism

Blocks TREK-1 potassium channels — a mechanism distinct from monoamine-reuptake-based antidepressants. Studied in rodent models of depression-like behaviour.

Research Context

The specific research interest is rapid-onset antidepressant activity through this TREK-1 blocking mechanism, positioned as a fundamentally different approach from SSRIs and other monoamine-reuptake-based antidepressants, which typically take weeks to show effect.

Evidence Status — Well-documented

Mechanism is well-documented preclinically; human trial data does not yet exist in the public literature.

This is one of the newer, less-established compounds in the index. The TREK-1 mechanism is well-documented in preclinical (rodent behavioral model) research, but human clinical trial data does not yet appear in the public scientific literature — an important distinction from compounds further along the research pipeline.

Research Use Only

This page is a scientific reference summarizing publicly available research literature. It contains no dosing, administration, or protocol guidance, and nothing here constitutes medical advice. BactoCore does not sell this or any peptide referenced in this index — the only product sold directly is bacteriostatic water. See the Safety section for who should not handle research compounds, and the Research Use Disclaimer for full terms.